李大鹏

院长 教授

个人简介：

美国罗格斯大学访问学者，兼任国际食物营养与安全协会理事，山东省食品科学技术学会副理事长等多项职务。担任Food Frontiers等杂志副主编及食品科学等多本杂志编委。主持和参与国家自然科学基金等省级以上课题20余项。以通讯作者在Journal of Advanced Research，Food Hydrocolloid，等杂志发表论文170余篇，H指数43。获中国商业联合会科学技术特等奖、山东省优秀博士论文奖等多项奖励，主编或参编教材6部，获得发明专利9项。

主要研究方向：

1. 食物中功能因子的健康调控机制研究

2. 功能因子靶向递送技术研究

3. 农产品废弃物的高值转化利用

代表性科研项目：

1. 2025.1-2028.12 EGCG调控组蛋白乳酸化修饰改善糖代谢紊乱的分子机制 （32472342）国家自然基金委，50万元，主持

2. 2025.1-2027.12 咖啡酸苯乙酯调控miR-182-5p改善镉诱导肝损伤的机制研究（ZR2024MC103）山东省科学技术厅，10万元，主持

3. 2021.12-2024.12设施蔬菜智慧生产与高值转化技术集成创新与示范（2021TZXD007）山东省科学技术厅，1336万元，主持

4. 2020.1-2023.12槲皮素与儿茶素协同抑制CHUK基因转录增强细胞抗氧化应激的分子机制（31972070）国家自然基金委，58万元，主持

5. 2018.6-2020.12罐头加工废弃物资源综合利用技术研究与示范，山东省农业农村厅，40万元，主持

6. 2019.1-2021.12基于Pickering乳液的抗氧化活性成分组高效递送技术研究（2019GNC106048）山东省科学技术厅，20万元，主持

7. 2016.1-2019.12槲皮素与儿茶素协同保护细胞抗氧化应激的信号通路及分子机制（31571836）国家自然基金委，66万元，主持

8. 2022.6-2023.12果蔬功能成分干预糖酯代谢紊乱机制及产品开发，科学技术部高端外国专家引进项目，40万元，主持

代表性科研论文：

1. Zhang, Z.; Hao, R.; Li, F.; Tian, S.; Xin, X.; Li, G.; Li, D. Emulsifying properties of cellulose nanocrystals with different structures and morphologies from various solanaceous vegetable residues. Food Chemistry 2025, 463, 141241.

2. Huang, D.; Zhang, W.; Liu, Y.; Zhang, J.; Jiang, Y.; Huang, Q.; Li, D. Effect of Combined pH-Shifting and High-Intensity Ultrasound Treatment on the Structural, Functional, and Foaming Properties of Tenebrio Molitor Protein. Food Hydrocolloids 2025, 111384.

3. Zhang, W.; Guan, H.; Wang, M.; Wang, W.; Pu, J.; Zou, H.; Li, D. Exploring the Relationship between Small Peptides and the T1R1/T1R3 Umami Taste Receptor for Umami Peptide Prediction: A Combined Approach. Journal of Agricultural and Food Chemistry 2024.

4. Guan, H.; Zhang, W.; Liu, H.; Jiang, Y.; Li, F.; Wang, D.; Liu, Y.; He, F.; Wu, M.; Waterhouse, G. I. N.; et al. Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats. Journal of Advanced Research 2024.

5. Wang, Y.; Rong, X.; Guan, H.; Ouyang, F.; Zhou, X.; Li, F.; Tan, X.; Li, D. The Potential Effects of Isoleucine Restricted Diet on Cognitive Impairment in High‐Fat‐Induced Obese Mice via Gut Microbiota–Brain Axis. Molecular Nutrition & Food Research 2023, 67 (20), 2200767.

6. Liu, H.; Guan, H.; He, F.; Song, Y.; Li, F.; Sun-Waterhouse, D.; Li, D. Therapeutic actions of tea phenolic compounds against oxidative stress and inflammation as central mediators in the development and progression of health problems: A review focusing on microRNA regulation. Critical Reviews in Food Science and Nutrition 2023, 1-31.

7. Hao, R.; Zhou, X.; Zhao, X.; Lv, X.; Zhu, X.; Gao, N.; Jiang, Y.; Wu, M.; Sun-Waterhouse, D.; Li, D. Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier. Science of The Total Environment 2023, 877, 162910.

8. Liu, H.; Guan, H.; Tan, X.; Jiang, Y.; Li, F.; Sun-Waterhouse, D.; Li, D. Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96–5p. Free Radical Biology and Medicine 2022, 181, 105-117.

9. Guan, H.; Zhang, W.; Sun-Waterhouse, D.; Jiang, Y.; Li, F.; Waterhouse, G. I.; Li, D. Phenolic-protein interactions in foods and post ingestion: Switches empowering health outcomes. Trends in Food Science & Technology 2021, 118, 71-86.

10. Rong, X.; Sun‐Waterhouse, D.; Wang, D.; Jiang, Y.; Li, F.; Chen, Y.; Zhao, S.; Li, D. The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity. Comprehensive reviews in food science and food safety 2019, 18 (1), 48-66.

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