关惠

讲师

个人简介：

关惠，女，工学博士，园艺学博士后，讲师，硕士生导师。担任《Food & Medicine Homology》国际期刊青年编委。目前主要从事食品营养健康领域的教学与科研工作，主讲食品营养与安全学课程。主持山东省自然科学基金青年项目1项，参与国家及山东省自然科学基金等科研项目2项。在Journal of Advanced Research、Trends in Food Science and Technology等学术期刊发表SCI论文20余篇。

主要研究方向：

1.食品营养与人类健康；

2.天然活性成分的交互作用及健康调控机制；

3.小分子化合物与蛋白质交互作用与疾病预防。

代表性科研项目：

山东省自然科学基金青年基金，No. ZR2024QC011，12万，主持。

代表性科研论文：

1. Guan, H.; Zhang, W. Y.; Liu, H.; Jiang, Y.; Li, F.; Wang, D.; Liu, Y.; He F.; Wu, M.; Waterhouse, G.; Sun-Waterhouse, D.; Li, D., Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats. Journal of Advanced Research2025, 67:71-92.

2. Guan, H.; Zhang, W. Y.; Sun-Waterhouse, D.; Jiang, Y.; Li, F.; Waterhouse, G.; Li, D., Phenolic-protein interactions in foods and post ingestion: Switches empowering health outcomes. Trends in Food Science and Technology2021, 118: 71-86.

3. Guan, H.; Zhang, W. Y.; Liu, H.; Jiang, Y.; Li, F.; Waterhouse, G.; Sun-Waterhouse, D.; Li, D., Quercetin induces apoptosis in HepG2 cells via directly interacting with YY1 to disrupt YY1-p53 interaction. Metabolites2023,13(2):1-17.

4. Liu, H.; Guan, H.; Tan, X.; Jiang, Y.; Li, F.; Sun-Waterhouse, D.; Li, D., Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96–5p. Free Radical Biology and Medicine2022, 181: 105-117.

5. Zhang, W. Y.; Guan, H.; Wang, M.; Wang, W.; Pu, J.; Zou, H.; Li, D., Exploring the Relationship between Small Peptides and the T1R1/T1R3 Umami Taste Receptor for Umami Peptide Prediction: A Combined Approach. Journal ofAgricultural and Food Chemistry2024, 72(23):13262-13272.

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